| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 4/22/25 5:00 PM | Alianza Lima | CA Talleres | Group D | 3-2 |
| 4/22/25 5:00 PM | LDU Quito | Flamengo | Group C | 0-0 |
| 4/22/25 5:00 PM | Carabobo FC | Universidad de Chile | Group A | 1-1 |
| 4/22/25 7:30 PM | Internacional | Club Nacional de Football | Group F | 3-3 |
| 4/22/25 7:30 PM | Colo-Colo | Racing Club | Group E | 1-1 |
| 4/22/25 9:00 PM | Barcelona SC | Universitario | Group B | 0-1 |
| 4/23/25 5:00 PM | Club Olimpia | Club Atlético Peñarol | Group H | 0-0 |
| 4/23/25 5:00 PM | San Antonio Bulo Bulo | CA Velez Sarsfield | Group H | 2-1 |
| 4/23/25 7:30 PM | Club Libertad | FC Sao Paulo | Group D | 0-2 |
| 4/23/25 7:30 PM | Independiente del Valle | River Plate | Group B | 2-2 |
| 4/23/25 7:30 PM | Estudiantes de La Plata | Botafogo | Group A | 1-0 |
| 4/23/25 9:00 PM | Atlético Bucaramanga | Fortaleza | Group E | 1-1 |
| 4/24/25 5:00 PM | Club Bolívar | Palmeiras | Group G | 2-3 |
| 4/24/25 5:00 PM | Central Cordoba | Deportivo Tachira | Group C | 2-1 |
| 4/24/25 7:00 PM | Bahia BA | Atlético Nacional | Group F | 1-0 |
| 4/24/25 7:30 PM | Club Cerro Porteno | Sporting Cristal | Group G | 2-2 |